目的：探讨增殖性糖尿病视网膜病变(PDR)经扁平部玻璃体切除(PPV)术后黄斑区视网膜、脉络膜血流的变化。

方法：横断面研究。选取2020-09/2022-07在合肥市第二人民医院眼科诊断为单眼PDR并接受23G PPV手术治疗的患者35例35眼，所有患者均行扫频源光学相干断层扫描血管造影(SS-OCTA)检查，采用系统内置分析软件测量黄斑区3mm×3mm范围内视网膜、脉络膜血流参数，并分析其与术后最佳矫正视力(BCVA)的相关性。

结果：术后随访1～22(平均9.72±6.67)mo，末次随访时，纳入患者PPV术眼鼻侧旁中心凹区域中层毛细血管层(ICP)灌注面积(FA)(0.31±0.06mm²)较对侧眼(0.38±0.05mm²)明显减少，颞侧旁中心凹区域深层毛细血管层(DCP)FA(0.19±0.08mm²)较对侧眼(0.27±0.07mm²)明显减少(均P<0.05)，除颞侧旁中心凹区域，PPV术眼其他旁中心凹区域脉络膜血管指数(CVI)均较对侧眼显著降低(P<0.05)。PPV术眼术后BCVA与视网膜中、深层血管密度和灌注面积均有一定的相关性。

结论：严重PDR患者患眼PPV术后较对侧眼可能更易出现旁中心凹区域视网膜深层及脉络膜血流灌注的减少。

METHODS: A cross-sectional study was conducted on 35 patients(35 eyes)who were diagnosed as monocular PDR and received 23GPPV in ophthalmology department of the Second People's Hospital of Hefei between September 2020 and July 2022. All eyes underwent swept-source optical coherence tomography angiography(SS-OCTA)examination. Retinal and choroidal vascular parameters within 3mm×3mm of macular zone were measured by built-in analyzer, and its correlation with postoperative best corrected visual acuity(BCVA)was analyzed.

RESULTS: The follow-up was 1～22(average 9.72±6.67)mo. At the last follow-up, flow area(FA)of intermediate capillary plexus(ICP)layer in paranasal foveal region was significantly reduced in PPV eyes(0.31±0.06mm²)compared with contralateral eyes(0.38±0.05mm²), and FA of deep capillary plexus(DCP)in temporal foveal region was significantly lower in PPV eyes(0.19±0.08mm²)than contralateral eyes(0.27±0.07mm²; all P<0.05). Choroidal vascularity index(CVI)were lower in PPV eyes than contralateral eyes in parafoveal subregions except temporal region(P<0.05). After PPV, BCVA had a certain correlation with the density and FA of middle and deep retinal vessels.

CONCLUSIONS: Eyes with severe PDR may be prone to having a decrease in the DCP and parafoveal choroidal perfusion in the parafoveal regions after PPV than contralateral eyes.