1.Yantai Affiliated Hospital of Binzhou Medical College;2.Yantai Affiliated Hospital of Binzhou Medical College、The Second Clinical Medical College of Binzhou Medical University
Corneal stromal is a significant part of the cornea and plays a significant role in the eye's refractive system. Although corneal transplantation is now the most successful treatment for corneal stromal disease, its advancement has been constrained by a shortage of donors, the need for prolonged immunosuppressive medicine to prevent rejection, and low graft survival rates. An alternate strategy is to use the corneal stroma's natural capacity for regeneration to create the ideal conditions for the collagenous extracellular matrix of the stroma to self-renew. However, it is challenging to replicate the intricate ultrastructure of the corneal stroma in vitro. Regenerative medicine has so been used to address these issues. These approaches combine numerous disciplines, including stem cell-induced differentiation, tissue engineering and gene editing. This article provides potential directions for future clinical applications of corneal stromal regeneration and repair while summarizing pertinent techniques, research progress, and issues.