1.The Second Clinical Medical College of Jinan University;2.Shenzhen People's Hospital;3.The Second Clinical Medical College of Jinan Univer;4.Shenzhen People&5.amp;6.#39;7.s Hospital
补体系统是一个具有精密调控机制的蛋白质反应系统，具有介导炎症、调节免疫应答、溶解细胞和清除免疫复合物等功能。糖尿病视网膜病变（Diabetic retinopathy, DR）是糖尿病常见和严重的眼部并发症，是眼科常见的不可逆性致盲性眼病之一。DR的发病机制错综复杂，包括缺氧、氧化应激、炎症反应、多元醇代谢通路的异常等。近年来有越来越多的证据表明，DR的发生发展与补体系统激活密切相关，多种补体蛋白在炎症调节、血管新生等关键过程中发挥着重要作用，从而影响了DR的病理进程。因此，研究补体系统及相关调节蛋白在DR中的作用将为我们防治DR提供重要参考和新的思路。本综述旨在阐明多种补体蛋白与DR的发生发展是如何联系的，以及针对补体系统的靶向补体药物的临床研究进展。
The complement system is a protein response system with a precise regulatory mechanism, which has the functions of mediating inflammation, regulating immune response, dissolving cells and clearing immune complexes. Diabetic retinopathy (DR) is a common and severe ocular complication of diabetes and one of the most common irreversible blinding eye diseases in ophthalmology. The pathogenesis of DR is complex, including hypoxia, oxidative stress, inflammation and abnormal polyol metabolism pathway. In recent years, there has been increasing evidence that DR is closely related to the activation of the complement system. Multiple complement proteins play important roles in key processes such as inflammation regulation and angiogenesis, thereby affecting the pathological process of DR. Therefore, studying the role of complement system and related regulatory proteins in DR Will provide important reference and new ideas for prevention and treatment of DR. This review aims to elucidate the association between multiple complement proteins and the development of DR, as well as the clinical research progress of the targeted complement drugs.