微小RNA在脉络膜新生血管相关信号路通中的研究进展
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作者单位:

1.甘肃中医药大学;2.中国人民解放军联勤保障部队第九四〇医院眼科中心

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基金项目:

国家自然科学基金项目(面上项目,重点项目,重大项目)


Research progress of microRNA in Choroidal neovascularization signaling pathway
Author:
Affiliation:

1.Gansu University of Chinese Medicine;2.The 940 Hospital of Joint Service Support Forces of the Chinese People's Liberation Army

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    脉络膜新生血管(Choroidal neovascularization,CNV)是多种眼部疾病的最终病理表现,其发病机制极其复杂,涉及多种细胞、细胞因子及信号通路。微小RNA(microRNA,miRNA或miR)做为一种生物小分子,随着学者对其深入研究,越来越多的miRNA介导信号通路参与疾病的研究逐一被揭示。在眼科领域,miRNA通过各种信号通路靶向特定蛋白基因影响CNV发展也是近几年研究的热点,其通过调控CNV关键的信号通路,促进或抑制CNV发生。在这篇文章中,综述了miRNA调控CNV发生发展相关的Wnt、PI3K-AKT、Notch、TGF-β及NF-κB信号通路的研究进展,为后续完善CNV发病机制及通过miRNA靶向干预为CNV治疗提供新思路。

    Abstract:

    Choroidal neovascularization (CNV) is the final pathological manifestation of a variety of ocular diseases, whose pathogenesis is extremely complex, involving a variety of cells, cytokines and signaling pathways. microRNA (miRNA or miR) is a kind of small biological molecule. With the in-depth study of microRNA, more and more miRNA-mediated signaling pathways involved in disease studies have been revealed one by one. In the field of ophthalmology, miRNAs affect the development of CNV by targeting specific protein genes through various signaling pathways, which is also a focus of research in recent years. By regulating key signaling pathways of CNV, miRNAs promote or inhibit the occurrence of CNV. In this article, we reviewed the research progress of the regulation of miRNA on Wnt, PI3K-AKT, Notch, TGF-β and NF-κB signaling pathways related to the occurrence and development of CNV, providing new ideas for the subsequent improvement of the pathogenesis of CNV and the treatment of CNV through miRNA-targeted intervention.

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  • 收稿日期:2023-06-28
  • 最后修改日期:2023-09-23
  • 录用日期:2023-08-28
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