目的：比较不同疗程布地奈德鼻喷雾剂对鼻内镜下泪囊鼻腔吻合术后疗效的影响。方法：前瞻性研究。选取2019-01/2022-04于我院行鼻内镜下泪囊鼻腔吻合术的慢性泪囊炎患者90例90眼。随机分为3组，A组30例30眼术后持续使用布地奈德鼻喷雾剂喷鼻2mo； B组30例30眼术后持续使用布地奈德鼻喷雾剂喷鼻3mo； C组30例30眼术后持续使用布地奈德鼻喷雾剂喷鼻4mo。随访至术后6mo，比较三组患者Lund-Kenndey评分、疗效及并发症情况。结果：术后3、4、6mo，C组患者Lund-Kenndey评分均低于A组(P<0.05)，但C组与B组患者Lund-Kenndey评分均无显著差异(P>0.05)。随访至术后6mo，C组患者疗效优于A组，并发症发生率低于A组(P<0.05)，但C组与B组患者疗效和并发症发生率均无显著差异(P>0.05)。结论：布地奈德联合鼻内镜下泪囊鼻腔吻合术治疗慢性泪囊炎效果良好，疗程3mo炎症控制稳定，可减少并发症的发生，提高手术有效率，增加疗程并不能进一步提高手术有效率。

AIM: To compare the effect of different courses of budesonide nasal spray on the postoperative efficacy of endoscopic dacryocystorhinostomy.METHOD: Prospective study. A total of 90 patients(90 eyes)with chronic dacryocystitis who underwent endoscopic dacryocystorhinostomy in our hospital from January 2019 to April 2022 were selected, and they were randomly divided into three groups. In group A, 30 patients(30 eyes)continued to use budesonide nasal spray for 2mo after surgery; in group B, 30 patients(30 eyes)continued to use budesonide nasal spray for 3mo after surgery; in group C, 30 patients(30 eyes)continued to use budesonide nasal spray for 4mo after surgery. Follow-up for 6mo after surgery, Lund-Kenndey score, surgical efficacy and complications of the three groups were compared.RESULT: At 3, 4 and 6mo after surgery, the Lund-Kenndey score of group C was lower than that of group A(P<0.05), and there was no statistical difference between group C and group B(P>0.05). Following up to 6mo, the surgical efficacy of group C was better than that of group A, and the incidence of complications was lower than that of group A(P<0.05); There was no statistically significant difference in efficacy and complications between group C and group B(P>0.05).CONCLUSION: Budesonide combined with endoscopic dacryocystorhinostomy has acceptable efficacy in the treatment of chronic dacryocystitis. After 3mo of treatment, inflammation can be well controlled, which can reduce the occurrence of postoperative complications and improve the effective rate of surgery. However, increasing the treatment course cannot further improve the effective rate of surgery.

承德市科技计划项目(No.202204A043)