小胶质细胞在视网膜血管生成中的作用机制研究进展
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南京医科大学附属淮安第一医院

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Research Progress on the Mechanisms of Microglia in Retinal Angiogenesis
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The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University

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    摘要:

    视网膜小胶质细胞作为视网膜的常驻免疫细胞,不断监测其周围环境的变化,并通过与其他视网膜细胞的信号传导来维持稳态。视网膜小胶质细胞不仅在视网膜血管系统的发育和生理过程中发挥重要作用,而且在病理性新生血管形成中也起着至关重要的作用。在某些视网膜病变中,活化的小胶质细胞通过神经血管耦联,促进异常血管生成,从而造成不可逆的损伤,但具体的作用机制尚不明确。本篇综述中,我们简要地描述了小胶质细胞与视网膜新生血管生成的相关性,并讨论了参与这一过程的细胞和分子信号机制,旨在为视网膜新生血管性疾病的预防和治疗提供新的有效的策略。

    Abstract:

    As resident immune cells of the retina, retinal microglia constantly monitor the changes of their surroundings and maintain homeostasis through signal transduction with other retinal cells. Retinal microglia play a crucial role not only in the development and physiological processes of the retinal vascular system, but also in pathological neovascularization. In certain retinopathies, activated microglia can stimulate abnormal angiogenesis through neurovascular coupling, leading to irreversible damage. However, the exact mechanisms underlying this process are still unclear. In this review, we provide a brief overview of the relationship between microglia and retinal neovascularization, and delve into the cellular and molecular signaling mechanisms involved, aiming to offer new and effective strategies for the prevention and treatment of retinal neovascularization diseases.

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历史
  • 收稿日期:2023-07-10
  • 最后修改日期:2023-09-03
  • 录用日期:2023-09-01
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