[关键词]
[摘要]
外泌体是一种细胞外囊泡，通过生物分子传递改变受体细胞的生化特性，并在细胞通讯中发挥作用。其中，间充质干细胞源性外泌体(MSC-Exos)是由间充质干细胞分泌的双层脂质囊泡，具有与间充质干细胞(MSCs)相似的功能，并携带蛋白质、脂质和核酸等生物活性物质，可作为细胞间通讯的媒介参与免疫调节、组织损伤修复和促进血管生成等多种重要生理过程，近年来在治疗免疫炎性疾病、缺血性疾病等相关领域成为研究的热点。本文从MSC-Exos的生物学功能出发，针对干眼不同发病机制如炎症反应、神经及组织修复等，阐述其治疗干眼的可能机制，以期为MSC-Exos在干眼治疗中的应用奠定基础，并为未来的临床应用提供参考依据。
[Key word]
[Abstract]
Exosomes are extracellular vesicles that facilitate cellular communication by transmitting biomolecules and altering the biochemical characteristics of receptor cells. Mesenchymal stem cell-derived exosomes(MSC-Exos)are lipid bilayer vesicles secreted by mesenchymal stem cells(MSCs). These exosomes have similar functions to MSCs and contain bioactive substances such as proteins, lipids, and nucleic acids. MSC-Exos play a vital role in intercellular communication and are involved in essential physiological processes including immune regulation, tissue damage repair, and angiogenesis promotion. Consequently, they have gained significant attention in research, particularly in the treatment of immune inflammatory diseases, ischemic diseases, and other related fields. This article provides an in-depth analysis of the potential treatment mechanisms for dry eye, focusing on the pathogenesis of the condition, including inflammatory reactions, nerve regeneration, and tissue repair. The objective is to establish a foundation for the application of MSC-Exos in the treatment of dry eye, thereby offering a valuable reference for the future clinical applications.
[中图分类号]
[基金项目]
山东省中医药科技项目(No.Q-2022077)
