目的：利用光学相干断层扫描血管成像(OCTA)探讨不同程度非增殖性糖尿病视网膜病变(NPDR)的表现差异。

方法：横断面研究。纳入糖尿病患者77例77眼，分为非DR组(NDR，23眼)和NPDR组(54眼)，其中轻度NPDR(20眼)、中度NPDR(20眼)和重度NPDR(14眼)。NDR组与NPDR组的黄斑区中央凹无血管区(FAZ)面积、浅层和深层毛细血管密度(SSP和DSP)、视力(LogMAR)进行比较，不同程度NPDR的视力、FAZ面积、SSP和DSP水平进行比较，FAZ面积、视力、SSP和DSP与病情严重程度进行相关性分析。

结果：与NDR组相比，NPDR组的视力值(LogMAR)、黄斑区FAZ面积增大，SSP和DSP降低(P<0.05)； 不同程度NPDR的视力、FAZ面积、SSP和DSP水平差异显著(P<0.05)。视力(LogMAR)、FAZ面积与病情严重程度呈正相关，SSP和DSP与病情严重程度呈负相关。

结论：随着NPDR病情的进展，视力(LogMAR)、FAZ面积增大，SSP和DSP降低。

METHODS: Cross-sectional study. A total of 77 cases(77 eyes)of diabetic patients were included, and they were divided into non-diabetic retinopathy(NDR; 23 eyes)and non-proliferative diabetic retinopathy(NPDR; 54 eyes)groups, further subdivided into mild NPDR(20 eyes), moderate NPDR(20 eyes), and severe NPDR(14 eyes). Foveal avascular zone(FAZ)area, superficial and deep capillary plexus densities(SSP and DSP), and visual acuity(LogMAR)were compared between NDR and NPDR groups. Furthermore, the visual acuity, FAZ area and levels of SSP and DSP were compared in different degrees of NPDR. Correlation analysis were conducted to elucidate relationships between FAZ area, visual acuity, SSP, DSP, and severity of the disease.

RESULTS: Compared with the NDR group, the visual acuity(LogMAR)and macular FAZ area increased, while SSP and DSP were decreased in the NPDR group(P<0.05); there were significant differences in visual acuity, FAZ area and SSP and DSP levels in different degrees of NPDR(P<0.05). Visual acuity(LogMAR)and FAZ area displayed a positive correlation with the severity of disease, while SSP and DSP showed a negative correlation.

CONCLUSION: With the progression of NPDR, the visual acuity(LogMAR)and FAZ area increased, and the SSP and DSP decreased.