N⁶-methyladenosine(m⁶A), the most common, abundant, and conserved RNA modification in eukaryotic cells, regulates RNA splicing, stability, output, degradation and translation through m⁶A methyltransferase, m⁶A demethylase, and m⁶A methylated binding proteins. Recent studies have found that abnormal m⁶A methylation may mediate a variety of pathological processes in eyes and participate in the occurrence and development of metabolic, inflammatory, degenerative ocular diseases and ocular tumors, such as diabetic retinopathy, cataract, age-related macular degeneration and uveal melanoma. This review aims to summarize the roles of m⁶A methylation modification in ocular cells and ocular diseases, elucidate the potential molecular mechanisms of m⁶A methylation in ocular diseases, so as to encourage innovative approaches in the treatment of these ocular diseases.