With the significant changes in people's lifestyles, the prevalence of myopia is escalating globally, which has aroused the close attention of clinicians. Myopia is easy to combine with other serious ophthalmic diseases, especially in patients with high myopia(HM), often combined with primary open angle glaucoma(POAG), and the incidence rate is much higher than that of people with normal refractive status. The condition becomes especially complex when HM co-exists with POAG. In recent years, we have focused on the characteristics of fundus changes in patients in clinical work. Early detection of patients with POAG from HM is the key to in-depth understanding and effective prevention and treatment of these two diseases. In this paper, we review the recent literatures on the relationship between HM and POAG from the aspects of epidemiology, pathogenesis, and clinical features, and summarize the research progress, so as to provide help for early detection, early diagnosis, and early treatment of the disease.