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[摘要]
年龄相关性黄斑变性(ARMD)是好发于年龄超过55岁人群的进行性视力损伤眼底疾病。其主要风险因素为机体衰老、长期吸烟、遗传以及人种差异等,发病机制包括视网膜色素上皮功能异常、血视网膜屏障受损及免疫功能异常等。目前,玻璃体腔注射(IVI)抗VEGF药物是临床治疗ARMD的首选方案,然而其同样面对着治疗反复、医疗费用昂贵以及患者依从性较差等问题。ARMD治疗的困境催生出许多新的治疗方案,文章旨在对干性ARMD与湿性ARMD的治疗方式及其进展进行综述,为解决当前临床抗VEGF治疗的局限性提供新思路。
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[Abstract]
Age-related macular degeneration(ARMD)is a progressive visual impairment fundus disease that frequently occurs in individuals aged >55 years. The main risk factors are aging, long-term smoking, genetics, and racial differences. Pathogenesis includes abnormal function of the retinal pigment epithelium, damaged blood-retinal barrier, and abnormal immune function. Currently, intravitreal injection(IVI)of anti-vascular endothelial growth factor(VEGF)drugs is the preferred treatment option for ARMD in clinical practice. However, it also faces challenges such as repeated treatments, high medical costs, and poor patient compliance. The predicament in the treatment of ARMD has given rise to several new treatment options. This article aims to review the treatment methods and progress of dry ARMD and wet ARMD, providing new ideas for addressing the limitations of the current clinical anti-VEGF treatment.
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