·AIM:To analyze and sum up therapeutic effect of 2.5g/L timolol maleate eye drops on the refractive regression after excimer laser in situ keratomileusis(LASIK).·METHODS:Fifty-three cases(66 eyes)with refractive regres-sion from 1 400 cases(2 650 eyes)of excimer LASIK surgery in our hospital centers 2007-08/2008-08 after follow-up of more than 0.5 year were randomly divided into two groups according to operation time.The test group was treated with 2.5g/L timolol maleate eye drops.The control group was treated with 1g/L sodium hyaluronate eye drops.Treatment time of both groups was 2 weeks.At the end of treatment,the test group and the control group were analyzed comparatively(visual acuity increased by the number of lines).·RESULTS:The test group visual acuity was improved-1-4 lines(average 1.45±1.09 lines),the control group visual acuity was improved-2-2 lines(average 0.61±0.86 lines),Group t tests showed differences between the two groups was statistically significant(t=3.500,P<0.05).·CONCLUSION:Timolol maleate eye drops 2.5g/L have significant effect on postoperative refractive regression after LASIK.·