AIM: To study clinical effects of optimizating surgical excision of pterygium and limbal conjunctival transplantation with stem cell.

METHODS: Primary pterygium patients 59 eyes of 59 cases were selected and randomly divided into two groups. Optimizating surgical excision of pterygium and limbal conjunctival transplantation with stem cell was performed in the experimental group(32 eyes of 32 cases); surgical excision of pterygium and limbal conjunctival transplantation with stem cell was performed in the control group(27 eyes of 27 cases); respectively using the corresponding approach of surgical treatment. The healing time of postoperative corneal epithelial and the conjunctival flap, the time of operative course, the rate of recurrence and postoperative comfort were compared and statistically analyzed.

RESULTS: The experimental group and the control group of the healing time of corneal epithelial respectively were 2.16±0.37 and 2.87±0.31 days, the time of operative course were 30.03±1.98 minutes and 36.63±2.42 minutes, the healing time of conjunctival flap were 8.06±0.75 days and 10.02±1.01 days, the scores of postoperative discomfort were 0.91±0.69 and 1.63±0.74. The differences were statistically significant(P<0.01), both groups had no recurrence case.

CONCLUSION: Using the optimizating surgical excision of pterygium and limbal conjunctival transplantation with stem cell can shorten the healing time of postoperative corneal epithelial and the conjunctival flap and patient feel more comfort after surgery.