AIM: To analyze the application on frequency domain optical coherence tomography(OCT)technology of pathologic myopia optic disc neurosensory retinal thickness changes and its relationship with axis oculi, sex and age, and help for the early diagnosis of pathological myopia and primary open angle glaucoma.

METHODS: Collected 96 eyes of normal eyes(axis oculi 23-24mm)and 153 eyes of pathologic myopia eyes(axis oculi 25-27mm 80 eyes, >27mm 73 eyes). We measured the thickness of nerve fiber layer of the optic disc by OCT and analyzed their relationship with axis oculi, sex and age with multiple linear regression analysis.

RESULTS: The observation group showed significant smaller average thickness of peripapillary, superior, inferior, nasal than the control group(P<0.05); the difference in the temporal quadrant between the groups were no statistically significant differences(P>0.05); The partial correlation coefficient of peripapillary average thickness of nerve fiber layer and axis oculi was -1.31, gender was 5.21, age was -0.12.

CONCLUSION: The thickness of nerve fiber layer of the optic disc in the pathologic myopia eyes are decreased than normal eyes, axis oculi, sex and age are influenced factors. The pathologic myopia patients should use different index combined with optic nerve fiber layer thickness decreased to help for the diagnosis of early primary open angle glaucoma.