AIM: To investigate the clinical characteristics and influencing factors of chronic renal failure(CRF)patients with dry eye, and to provide clinical reference.

METHODS: Sixty-one cases(122 eyes)of patients with CRF(CRF group)and 61 cases(122 eyes)of healthy persons(control group)were carried out on Schirmer Ⅰ test(SⅠt), break-up time of tear film(BUT), corneal fluorescein staining(FL), test results of two groups were compared and related factors of dry eye in CRF patients were analyzed.

RESULTS: The results of SⅠt and BUT in CRF group were lower than that in the control group(P<0.05). The proportion of tear secretion reduce in CRF group(SⅠt<10mm/5min)was 49.2%(60/122), which was higher than that in the control group(10.0%, 12/122), the difference was statistically significant(χ²=45.39, P<0.05). The percentage of instability of tear film in CRF group(BUT≤10s)was 75.4%(92/122), which was significantly higher than that in the control group(27.0%, 33/122)(χ²=57.1, P<0.05). The positive rate of corneal FL was 37.7%(46/122), which was higher than that of the control group(10.7%, 13/122), there was a statistically significant difference(χ²= 24.34, P<0.05).

CONCLUSION: CRF patients with a decrease in tear film stability and tear secretion are susceptible population to dry eye, clinically should be paid attention to the treatment.