目的：探讨2型糖尿病(diabetes mellitus，DM)患者黄斑区视网膜厚度与糖化血红蛋白(HbA1c)的相关性。

方法：收集2016-05/2017-04在我院住院的2型糖尿病患者39例77眼，根据HbA1c水平分为低HbA1c组(HbA1c<8.0%)24例47眼和高HbA1c组(HbA1c≥8.0%)15例30眼，选择同期进行健康体检的正常人群22例44眼作为正常对照组。采用Spearman相关分析法分析HbA1c水平与黄斑区视网膜厚度的相关性。

结果：高HbA1c组患者HbA1c(10.45%±1.30%)、FBG(10.67±1.64mmol/L)、2hPG(15.98±1.38mmol/L)水平均高于低HbA1c组，差异均有统计学意义(P<0.05)。正常对照组黄斑区视网膜厚度(CSRT)、黄斑部体积(CV)及平均黄斑区厚度(CAT)均低于高HbA1c组和低HbA1c组，差异均有统计学意义(P<0.05)。根据Spearman法分析，2型DM患者CSRT、CV、CAT与HbA1c、FBG、2hPG水平均呈正相关(P<0.01)。

结论：HbA1c水平与DM患者黄斑区视网膜增厚具有相关性，可一定程度上预测糖尿病视网膜病变的严重程度，为其防治提供重要指导。

METHODS: Totally 39 cases of patients with diabetes(77 eyes)who screened from May 2016 to March 2017 were selected, and were divided into two groups according to the levels of HbA1c, which the 24 cases(47 eyes)in the low HbA1c group(HbA1c<8%)and 15 cases(30 eyes)in high HbA1c group(HbA1c≥8%). Other 22 cases of normal people(normal control group)and who for healthy physical examination were selected in the same period. Then, the correlation between HbA1c level and CSRT were analyzed by the Spearman correlation analysis.

RESULTS: In the high HbA1c group, HbA1c was(10.45±1.30)%, FBG was 10.67±1.64mmol/L and 2hPG was 15.98±1.38mmol/L, which was higher than that in the low HbA1c group, and there was significant difference between the two groups(P<0.05). The CSRT in the normal group was lower than the low HbA1c group and the high HbA1c group, and there was significant difference between the groups(P<0.05). According to the analysis of the Spearman method, there was positive correlation between HbA1c and CSRT, macular volume, average macular thickness, FBG and those parameters, 2hPG and them(P<0.01).

CONCLUSION: The HbA1c level is associated with retinal thickening in the macular region of patients with diabetes, which could predict the severity of diabetic retinopathy and provide important guidance for prevention and treatment.