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引用:宋兆威,李志坚,王晓慧,李华章.NLRP3参与的细胞焦亡在眼科疾病的研究进展.国际眼科杂志 2020;20(8):1347-1350,doi:10.3980/j.issn.1672-5123.2020.8.10
NLRP3参与的细胞焦亡在眼科疾病的研究进展
Advances in research on NLRP3 pyroptosis in ophthalmology
投稿时间:2019-10-14  修订日期:2020-06-28
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DOI:10.3980/j.issn.1672-5123.2020.8.10
关键词:  NLRP3  细胞焦亡  年龄相关性黄斑变性  白内障  翼状胬肉  糖尿病视网膜病变  干眼症
Key Words:  NLRP3  pyroptosis  age-related macular degeneration  cataract  pterygium  diabetic retinopathy  dry eye syndrome
基金项目:国家自然科学基金面上项目(No.81870643)
Fund Project:National Natural Science Foundation of China(No.81870643)
           
作者单位
宋兆威 中国黑龙江省哈尔滨市,哈尔滨医科大学附属第一医院眼科医院
李志坚 中国黑龙江省哈尔滨市,哈尔滨医科大学附属第一医院眼科医院
王晓慧 中国黑龙江省哈尔滨市,哈尔滨医科大学附属第一医院眼科医院
李华章 中国黑龙江省哈尔滨市,哈尔滨医科大学附属第一医院眼科医院
           
AuthorInstitution
Zhao-Wei Song Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China
Zhi-Jian Li Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China
Xiao-Hui Wang Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China
Hua-Zhang Li Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China
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摘要:
      

核苷酸结合寡聚化结构域(NOD)样受体家族含 Pryrin 结构域蛋白 3(NLRP3)炎性体是位于细胞内的一种蛋白质复合体,大量的活性氧(ROS)释放后可激活细胞内NLRP3炎性小体的产生,这个炎性小体由NLRP3、 半胱氨酸蛋白酶募集结构域(ASC)及半胱氨酸蛋白酶-1前体(pro-caspase-1 )组成,NLRP3炎性小体在组装成型的同时活化 caspase-1。 随后caspase-1 对细胞因子白介素1和白介素 18(pro-IL-1/18)进行切割,使其成为成熟形式行使其促炎功能。细胞焦亡是炎症小体介导的依赖于caspase-1 的细胞程序性死亡。本文就 NLRP3炎性小体的结构、功能及其与细胞焦亡之间的关系以及在眼科疾病中的研究进展做以综述。

Abstract:
      Nucleotide-binding oligomerization domain(NOD)-like receptor family contains Pryrin domain protein 3(NLRP3)inflammasome, which is an intracellular protein complex. Large release of ROS can activate the production of intracellular NLRP3 inflammasome. It consists of NLRP3, a cysteine protease recruitment domain(ASC),and a pro-caspase-1 precursor, can activate caspase-1 while being assembled. Then, the cytokines interleukin-1 and interleukin-18(pro-Il-1/18)are cleaved into mature forms by caspase-1 to perform their pro-inflammatory functions. pyroptosis refers to the programmed cell death of Caspase-1-dependent cells mediated by inflammasome. This article reviews the structure and function of NLRP3 inflammasome, its relationship with pyroptosis, and the research progress in ophthalmic diseases.
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