引用:宋兆威,李志坚,王晓慧,李华章.NLRP3参与的细胞焦亡在眼科疾病的研究进展.国际眼科杂志 2020;20(8):1347-1350,doi:10.3980/j.issn.1672-5123.2020.8.10 |
NLRP3参与的细胞焦亡在眼科疾病的研究进展 |
Advances in research on NLRP3 pyroptosis in ophthalmology |
投稿时间:2019-10-14 修订日期:2020-06-28 |
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DOI:10.3980/j.issn.1672-5123.2020.8.10 |
关键词: NLRP3 细胞焦亡 年龄相关性黄斑变性 白内障 翼状胬肉 糖尿病视网膜病变 干眼症 |
Key Words: NLRP3 pyroptosis age-related macular degeneration cataract pterygium diabetic retinopathy dry eye syndrome |
基金项目:国家自然科学基金面上项目(No.81870643) |
Fund Project:National Natural Science Foundation of China(No.81870643) |
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Author | Institution |
Zhao-Wei Song |
Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China |
Zhi-Jian Li |
Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China |
Xiao-Hui Wang |
Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China |
Hua-Zhang Li |
Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin , Heilongjiang Province, China |
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摘要: |
核苷酸结合寡聚化结构域(NOD)样受体家族含 Pryrin 结构域蛋白 3(NLRP3)炎性体是位于细胞内的一种蛋白质复合体,大量的活性氧(ROS)释放后可激活细胞内NLRP3炎性小体的产生,这个炎性小体由NLRP3、 半胱氨酸蛋白酶募集结构域(ASC)及半胱氨酸蛋白酶-1前体(pro-caspase-1 )组成,NLRP3炎性小体在组装成型的同时活化 caspase-1。 随后caspase-1 对细胞因子白介素1和白介素 18(pro-IL-1/18)进行切割,使其成为成熟形式行使其促炎功能。细胞焦亡是炎症小体介导的依赖于caspase-1 的细胞程序性死亡。本文就 NLRP3炎性小体的结构、功能及其与细胞焦亡之间的关系以及在眼科疾病中的研究进展做以综述。 |
Abstract: |
Nucleotide-binding oligomerization domain(NOD)-like receptor family contains Pryrin domain protein 3(NLRP3)inflammasome, which is an intracellular protein complex. Large release of ROS can activate the production of intracellular NLRP3 inflammasome. It consists of NLRP3, a cysteine protease recruitment domain(ASC),and a pro-caspase-1 precursor, can activate caspase-1 while being assembled. Then, the cytokines interleukin-1 and interleukin-18(pro-Il-1/18)are cleaved into mature forms by caspase-1 to perform their pro-inflammatory functions. pyroptosis refers to the programmed cell death of Caspase-1-dependent cells mediated by inflammasome. This article reviews the structure and function of NLRP3 inflammasome, its relationship with pyroptosis, and the research progress in ophthalmic diseases. |
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