方法：前瞻性随机对照研究。选取2016-06/2019-12在我院行白内障超声乳化联合Toric IOL植入术的年龄相关性白内障患者47例56眼随机分为两组：导航组术前Verion导航系统采集眼前节图像，设定Toric目标轴向27眼，标记器组术前使用Toric标记器标记水平0°、180°，术中根据标记环标记Toric目标轴向29眼。术后1h，1wk，1、3mo患者散瞳后眼前节照相，Photoshop软件分析两组患者实际轴向和目标轴向的偏差值，并记录患者裸眼视力(UCDVA)、最佳矫正视力(BCDVA)以及残余散光度。

结果：术后1h，3mo导航组患者IOL实际轴向和目标轴向的偏差值小于标记器组(1.5°±1.8° vs 3.1°±2.1°； 1.9°±1.6° vs 3.3°±2.4°，均P<0.05)。术后3mo，导航组和标记器组平均UCDVA(LogMAR)比较无差异(0.04±0.08 vs 0.06±0.07，P=0.338)； 残余散光度比较无差异(-0.39±0.32 vs -0.45±0.31D，P=0.491)。

结论：Verion导航和手动标记方法标记Toric IOL轴向都有较高的准确性，尽管导航组并未显示出UCDVA和残余散光度方面的优势，但是IOL轴向偏差导航组显著小于标记器组，导航标记下植入Toric IOL轴向更精准。

METHODS:Prospective randomized controlled study. A total of 56 eyes of 47 age-related cataract patients who underwent phacoemulsification combined with Toric IOL implantation in our hospital from June 2016 to December 2019 were randomly divided into two groups:In the image-guided group, Verion navigation system collected anterior segmental images before surgery, and Toric target was set to 27 eyes in axial direction. In the marker group, Toric target was marked at 0° and 180° levels before surgery, and Toric target was marked in 29 eyes in axial direction according to the labeling ring. At 1h, 1wk, 1 and 3mo postoperatively, the anterior segment of patients with dilated pupil was photographed. Photoshop software was used to analyze the deviation between the actual axial direction and the target axial direction of the two groups, and the patients' naked eye visual acuity(UCDVA), best corrected visual acuity(BCDVA)and residual astigmatism were recorded.

RESULTS: At 1h and 3mo postoperatively, the deviation between the actual axis and the target axis of IOL in the navigation group was less than that in the marker group(1.5°±1.8° vs 3.1°±2.1°; 1.9°±1.6° vs 3.3°±2.4°, all P<0.05). There was no difference in UCDVA(LogMAR)between the navigation group and the marker group(0.04±0.08 vs 0.06±0.07, P=0.338)and there was no difference in residual divergence(-0.39±0.32 vs -0.45±0.31D, P=0.491)between two groups at 3mo after operation.

CONCLUSION:Verion digital marking and manual marking showed high accuracy in marking Toric IOL axial direction. Although the navigation group showed no advantage in UCDVA and residual astigmatism, the IOL misalignment in navigation group was significantly smaller than the marker group, and Toric IOL axial direction was implanted more accurately under Verion digital marking.