目的 观察雷珠单抗玻璃体腔注射（IVR）辅助治疗糖尿病黄斑水肿（DME）的效果。方法 选择2022年3月-2023年3月本院收治的98例（98眼）DME患者，采用随机数字表法分为2组，对照组49例（49眼）DME患者采用亚阈值微脉冲（STMP）黄激光治疗，研究组49例（49眼）DME患者采用IVR辅助STMP黄激光治疗。比较最佳矫正视力（BCVA）、视网膜新生血管（RNV）渗漏面积、黄斑中心凹旁厚度（PMT）、黄斑中心厚度（FMT）、中心视网膜厚度（CRT）、中心凹无血管区面积（FAZ）、生活质量、并发症发生情况，并检测两组患者的血清一氧化氮合酶（NOS）、血管内皮生长因子（VEGF）水平。结果 治疗后，两组的BCVA均优于治疗前（P<0.05），且研究组优于对照组（P<0.05）。治疗后，两组的RNV渗漏面积、PMT、FMT、CRT、FAZ、VEGF均小于治疗前（P<0.05），且研究组小于对照组（P<0.05）。治疗后，两组的NOS、中文版低视力者生活质量量表（CLVQOL）各维度评分均高于治疗前（P<0.05），且研究组高于对照组（P<0.05）。无一例发生眼部及全身并发症。结论 IVR辅助治疗DME，可提高患者视力，减小RNV渗漏面积、PMT、FMT、CRT、FAZ，调节血清NOS、VEGF水平，改善患者生活质量，且安全性好。

Objective To observe the effect of intravitreal ranibizumab injection (IVR) as an adjuvant treatment for diabetic macular edema (DME). Methods A total of 98 cases (98 eyes) of DME patients admitted to our hospital from March 2022 to March 2023 were randomly grouped into two groups using a random number table method. The control group (49 eyes) received subthreshold micro pulse (STMP) yellow laser treatment, while the study group (49 eyes) received IVR assisted STMP yellow laser treatment. The best corrected visual acuity (BCVA), retinal neovascularization (RNV) leakage area, parafoveal macular thickness (PMT), central macular thickness (FMT), central retinal thickness (CRT), foveal avascular zone (FAZ), quality of life, and complications were compared, and the levels of serum nitric oxide synthase (NOS) and vascular endothelial growth factor (VEGF) were measured in the two groups. Results After treatment, the BCVA of both groups was better than before treatment (P<0.05), and the study group was better than the control group (P<0.05). After treatment, the RNV leakage area, PMT, FMT, CRT, FAZ, and VEGF in both groups were smaller than before treatment (P<0.05), and the study group were smaller than the control group (P<0.05). After treatment, the NOS and scores of all dimensions of Chinese version of the Low Vision People's Quality of Life Scale (CLVQOL) in both groups were higher than before treatment (P<0.05), and the study group were higher than the control group (P<0.05). No eye or systemic complications occurred. Conclusion: IVR assisted treatment of DME can improve patients' vision, reduce RNV leakage area, PMT, FMT, CRT, FAZ, regulate serum NOS and VEGF levels, improve quality of life, and have good safety.