AIM:To investigate the effects of sanxuemingmu tablet(SXMMT) that can activate blood,relieve meridians,eliminate dampness and dissipate stagnation on the treatment of retinal vein occlusion(RVO) and the action mechanism of preventing the new blood vessel. METHODS:Forty-eight rabbits (96 eyes) were randomly divided into 4 groups,with 12 (24 eyes) in each one. Group A was normal group,group B was modeling group,group C was xueshuantong group and D was SXMMT group. RVO models were made by laser photocoagulation. Rabbits were killed in the 3rd,7th,14th and 21st day after the operation. Then eyeballs were taken,dehydrated and embedded in paraffin to observe the expression of VEGF and bFGF in the retina by immunohistochemistry. RESULTS:The RVO models of group B,C,D were successfully established. Compared with B group,the content of VEGF and bFGF of group D were obviously reduced,and had significant difference. CONCLUSION:SXMMT could promote absorbing blood after RVO,improve retina hypoxic-ischemic conditions,depress the excessive expression of VEGF and bFGF in retina surface after RVO,treat RVO and control new vessel,and then protect the retina. 