AIM:To evaluate the effects of Stulln Mono eye drops on asthenopia after laser in situ keratomileusis(LASIK). METHODS:Eighty consecutive subjects (160 eyes) were divided into two groups randomly (40 in stullen group,and 40 in control group) matched for age and refraction. We analyzed changes in the AC/A,AMP and BUT of single eye. Symptoms were scored according to defined criteria. All patients were evaluated before and one week,four weeks after LASIK surgery. Side effects,if any,were noted during the study. RESULTS:By the repeated measurement,the differences in time interaction effects of AMP,BUT,and AC/A in the two groups were not significant. There was a sudden drop in AMP and BUT(P<0.05) a week after the surgery.Then,AMP and BUT recovered to the pre-operative level. The AC/A ratio of naked eyes was smaller than that of wearing glasses before surgery and 1 week postoperatively.There was no significant difference between the stulln group and the control. Scores of headaches,blurred vision of near work,eye pain,dry eye,glare and halo changed significantly after LASIK. There was no statistical difference between the stulln and the control group in all symptoms a week after LASIK. Scores for blurred vision of nearwork and dry eye reduced four weeks later in Stulln group compared with the control group(P<0.05).CONCLUSION:Stulln Mono eye drops could ameliorate patients’ blurred vision at near work and dry eye four weeks after treatment. 