AIM:To explore the clinical feature and therapeutic method of acute acquired extraocular muscles paralysis.METHODS:The detailed medical record,system and ophthalmology medical examination were performed in 21 cases of acute acquired extraocular muscles paralysis and then dexamethasone and 654-2 were injected behind or beside the eyeball,and the xuesaitong or complex salviae parenteral solution and energy mixture were dripped in vein. RESULTS:There were 15 cases (71%) induced by surgical trauma (neurogenic paralysis),and 6 cases(29%) by the blood vessel pathological changes (muscular paralysis). All cases saw doctor firstly because of ambiopia. 17 cases fully recovered from the illness and 4 cases excellently recovered from the illness. CONCLUSION:The significant effect can be gained by early and positive drug treatment.