AIM:To observe the influence of the Fritillaria thun-bergii’s extract on the proliferation of the cultured orbital fibroblasts (OF) of the thyroid-associated ophthalmo-pathy (TAO)-patients.·METHODS:The cultured OF of the normal and the TAO-patients was introduced.The Fritillaria thunbergii’s extract and the Dexamethasone(Dex) as the positive contrast medicine were devided into different groups to detect the influence of the Fritillaria thunbergii’s extract on the proliferation of the cultured OF of the normal and the TAO-patients by the MTT method.·RESULTS:The Fritillaria thunbergii’s extract showed a similar result to Dex in inhibiting the prolife-ration of cultured OF of the TAO-patients,and both of them showed the dose-dependence.But the inhibition of the Fritillaria thunbergii’s extract to the proliferation of the TAO-patients’ OF was better than the normal obviously (P<0.05),and the Dex had no this selectivity.·CONCLUSION:The Fritillaria thunbergii inhibit the proliferation of TAO-patients’ OF.