AIM:To observe the effect of traditional Chinese medicine(TCM) of bushenhuoxue on the rat model of chronic,moderately elevated intraocular pressure(EIOP).·METHODS:By unilaterally cauterizing episcleral vessels,the rat model of chronic,moderately EIOP was gotten.52 rats were divided into 5 groups randomly:model control group,treatment groups with high,middle,low dosage of bushenhuoxue of TCM,and normal control group.After given drugs or normal saline for 8 weeks,the rats were put to death and eyeballs were taken out.The effects were observed by intraocular pressure(IOP),multifocal electroretinogram(mfERG),and retinal ganglion cells(RGCs).·RESULTS:Elevated IOP was gotten and there was an approximately 3-fold increase in IOP for 8 weeks later comparing to pre-models building.Bushenhuoxue of TCM can lower IOP slightly;To observe the mfERG first order kernel(FOK),bushenhuoxue of TCM can improve P1 wave’s 1,2,3,4 ring’s amplitude density,P1 wave’s peak time,N1 wave’s 2,3 ring’s amplitude density and N1 wave’s 2,3 ring’s peak time.·CONCLUSION:Bushenhuoxue of TCM can protect the visual function from elevating IOP by improving mfERG’s amplitude density and peak time.So the mfERG can be a sensitivity method to evaluate its efficacy.