·AIM:To study the protective effect of gross saponins from tribulus terrestris L(GSTT)and Erigeron Breviscapus(Vant.)Hand-Mazz(EBHM)on retinal ganglion cells(RGCs)in rabbits of chronic high intraocular pressure(HIOP)mode 1.·METHODS:Twenty-four rabbits were randomly divided into control group,HIOP group,EBHM treated group,GSTT treated group.The HIOP models were made by injected 20g/L methylcellulose into anterior chamber in rabbits of HIOP group and two treated groups.The rabbits in two treated groups were treated with EBHM and GSTT extract every day,4.5mg/kg and 5mg/kg respectively.When the HIOP lasted for four weeks,killing rabbits,removal of the eye,electron microscopy of RGCs were done.·RESULTS:After modeling in each group were elevated intraocular pressure,ultrastructure of RGCs have obvious damage under electron microscope for HIOP group in relation to the two treatment groups.·CONCLUSION:GSTT and EBHM have a protective effect on RGCs in rabbits with chronic high intraocular pressure.·