·AIM:To observe clinical effects of Avastin combined with vitreous cavity injection of triamcinolone acetonide in treatment of diabetic retinopathy(DR)with macular edema(ME).·METHODS:Thirty-four cases of the DR with ME inpatients or outpatients in our hospital from March 2007 to April 2008,with both eyes involved in each case,were randomly divided into observation group of 17 cases and control group of 17 cases.Observation group were treated with intravitreal Avastin(20g/L),triamcinolone acetonide(40g/L)co-injection and the control group received intravitreal triamcinolone acetonide(40g/L)injection.The visual acuity,intraocular pressure,retinal neovascularization and the ME situation were observed and recorded.·RESULTS:The cure rate of the observation group was 64.7%,while the cure rate of the control group was only 41.2%.Observation group was significantly better than control group in the cure rate(P<0.05).·CONCLUSION:Avastin combined with vitreous cavity injection of triamcinolone acetonide in treatment of DR with ME is an effective approach.·