·AIM:To study the changes and significance of the serum plasma homocysteine(Hcy),superoxide dismutase(SOD),malondialdehyde(MDA)and serum lipid levels within age-related macular degeneration(AMD)TCM syndrome types,and to observe if Hcy level is a risk factor in AMD among Chinese population.·METHODS:Fifty-two AMD patients’ blood samples were collected with 19 healthy samples as control.The fasting Hcy levels were measured by euzyme-linked immunosorbent assay.SOD,MDA,and blood fat concentration were also measured.And different AMD TCM syndrome types and all these indexes were analyzed to find the influence on Hcy from the related factors and the independent factor of AMD.·RESULTS:The Hcy levels in phlegm-blood stasis syndrome group and liver-kidney deficiency syndrome group were higher than those of the control(P<0.05),yet no differences were detected among three case groups.Results demonstrated negative correlation between Hcy and SOD level.SOD levels in phlegm-blood stasis syndrome group and liver-kidney deficiency syndrome group were higher than controls and phlegm syndrome group(P<0.05),while TC level was higher than controls(P<0.05);MDA,TC and LDL-C levels in all groups were elevated to different degrees(P<0.05).No difference of HDL-C level among four groups was found.·CONCLUSION:Hyperhomocysteine may play roles in phlegm-blood stasis syndrome and liver-kidney deficiency syndrome AMD by various pathogenic mechanisms,but was not a risk factor of AMD in this survey.Increased TC and LDL-C levels may be indexes of stage increasing in phlegm syndrome group.Increased TC,TG and LDL-C may be some of the useful markers of phlegm-blood stasis syndrome and liver-kidney deficiency syndrome.Decreased SOD and increased MDA may be regarded as pathological basis in AMD.·