AIM: To compare the surgical effect between transs-cleral cyclophotocoagulation and cyclocryotherapy for neovascular glaucoma. METHODS: In 2006 from January to December, 38 cases(43 eyes) diagnosed with neovascular glaucoma were treated. 18 cases(18 eyes) were treated with cyclo-cryotherapy and 20 cases(25 eyes) were treated with transscleral cyclophotocoagulation. The post-surgery clinical procedure was no diffrence between two groups. The intraocular pressure(IOP), eyesight, the clinical procedure, and the complications after surgery were observed. RESULTS: During follow-up of 3 months, the IOP of 11 eyes(61%) was controlled from 11 mmHg to 24 mmHg in the cases treated with cyclocryotherapy, and 20 eyes (80%) in the cases treated with cyclophotocoagulation respectively. In each group, there was highly statistical difference between the IOP of pre-operation and post-operation(P=0.000). And there was no statistical diffe-rence between the post-operation IOP of two groups(P=0.669). The visual acuity of 10 eyes (56%) was pre-served in the cases treated with cyclocryotherapy, and 21 eyes(84%) in the cases treated with cyclophotocongula-tion respectively, the result was statistically different(P=0.040). Postoperative complications were found fewer in the cases treated with cyclophotocoagulation, included hypema, pain, anterior chamber haemorrhage, and aqueous flare. CONCLUSION: To controll the IOP of eyes with neovascular glaucoma, transscleral cyclophotocoagula-tion and cyclocryotherapy are both effective and safe. Furthermore, cyclophotocoagulation has fewer postopera-tive complications and pain,it also has higher visual acuity preservation.