AIM: To observe the clinical effect of Lotemax on intraocular pressure(IOP) after laser epithelial keratomileusis(LASEK). METHODS: Two hundred cases after LASEK surgery were divided into group A of 100 cases (200 eyes) with postoperative Tobradex eyedrops for a week, group B of 100 cases (200 eyes) with joint eyedrops of Lotemax and Tobrex for a week. Ocular symptoms, vision,diopter, corneal thickness and IOP were observed in the follow-up. RESULTS: Group A was with high IOP in 12 eyes(6.0%). Group B with of high IOP in 3 eyes(1.5%). It was significantly different P<0.05. Lotemax eyedrops significantly reduced the incidence of increased IOP. CONCLUSION: Lotemax after LASEK surgery is safe and effective.