·Acanthamoeba keratitis is a sight-threatening infection,which is characterized by ring-like stromal infiltration and keratonueuritis.The pathophysiology cascade of this infection begins when the trophozoites bind to the corneal epithelium.Following processes include trophozoite-mediated cytopathic effects and the productions of several pathogenic proteases that degrade collagenous stroma.Because of the predilection of acanthamoeba for respond-ing chemotactically to nural cell,it can produce what appears to be keratoneuritis.However the pathophysio-logy of acanthamoeba keratitis is still unclear,targeting pathophysiology could lead to the development of the diagnosis and treatment of this disease.·