·Diabetic retinopathy(DR)is a diabetic microvascular disease affecting the eyes,which is a leading cause of blindness in adults under 75 years old.In recent years,regular screening for DR,blood glucose,blood pressure and blood lipid has contributed to lower incidence of blindness due to retinopathy.But still the pathogenesis of DR is unclear.At present,proteomics and related technologies provide a powerful tool to study the intrinsic pathophysiological mechanisms of DR at the molecular level.This technology can study an abundance of proteins at a time and identify the different expressed proteins.Comparative proteomics show that the DR is not activated by a single protein,but by a variety of proteins.At present,the functions of the identified proteins are not very clear,and there is a complex network between the various proteins.This article briefly reviews the recent progress of proteomics in DR.·