·AIM:To investigate the relationship between the thickness change of retinal nerve fiber layer and visual field damage in the primary open angle glaucoma(bluish glaucoma)for the syndrome differentiation of TCM.·METHODS:Seventy-two patients(144 eyes)of primary open angle glaucoma underwent optical coherence tomo-graphy for a 3.4mm ring around the optic disc.Each quadrant retinal nerve fiber layer thickness was recorded,and imported Humphry vision analyzer was used for quantification in the whole field of vision 30° test checks.Traditional Chinese medicine was applied on the patients with TCM theory.The relationship between the two was observed.·RESULTS:TCM syndrome and retinal nerve fiber layer thickness changes had statistical significance,TCM syndro-me type and the type of visual field damage was statistically significant(P<0.05).·CONCLUSION:The optic nerve damage is more common in the deficiency within the blue wind,optic nerve damage were seen in the early period.Therefore,the extent of optic nerve damage to a certain extent gives a certain degree of guidance in TCM treatment.·