AIM: To investigate the diagnostic value of multifocal electroretinography(mfERG) in Age-related macular degeneration (AMD). ·METHOD: MfERG was recorded in 66 AMD patients and 13 healthy (people) with RETI scan (Version 3.11) system. The P 1 and N 1 wave components were analyzed.·RESULTS: Response densities of P1 wave in ring 1-3 and N1 wave in ring 1 were decreased and latencies of P1 wave in ring 1, N1 wave in ring 2, 3, 5 were delayed in dry-form group (P<0.05). Response densities decreased and latencies delayed in all rings in wet-form group, meanwhile, compared with dry-form group, response densities of P1 wave in ring 1-4 and N1 wave in ring 2-3 were decreased(P<0.05) and latencies of P1 wave in ring 5 and N1 wave in ring 1-3 were delayed (P<0.05). Response densities in ring 1-2 of the asymptomatic fellow eyes of wet-form group were decreased compared with the control and asymptomatic fellow eyes of dry form groups(P<0.05). No changes were observed between one eye in dry-form with contralateral wet-form group and dry-form group(P>0.05).·CONCLUSION: Response density in ring 1-3 of P1 wave and ring 1 of N1 wave, latency in ring 1 of P1 wave and ring 2,3,5 of N1 wave may be a sensitive index of dry-form AMD. Response density in ring 1-4 of P1 wave and ring 2-3 of N1 wave, latency in ring 1-5 of P1 wave and ring 1-3 of N1 wave may reflex functional changes in posterior pole of wet-form AMD. The asymptomatic fellow eyes of wet AMD are vulnerable to become dry AMD, while no influence on dry-form eyes with contrala-teral wet-form AMD in this study.