AIM:To choose a relatively safe method of anesthesia by evaluating the ratio of no light perception preoperative for the patients with optic neuropathy (mainly referring to disc ischemia and atrophy) using two different methods on the vitrectomy. ·METHODS: Retrospectively analyzed the clinical data of 80 cases 80 eyes with pars plana vitrectomy in patients, all the patients had been confirmed that the color of optic nerve was light before or during surgery. They were used retrobulbar or peribulbar anesthesia across vitrectomy before surgery, and checked the light perception of the eye at the end of surgery. If no light perception, treat-ment was performed.·RESULTS: There are 9 cases (22.5%) of no light perce-ption in retrobulbar anesthesia group at the end of surgery, but none of them in peribulbar anesthesia group. After aggressive treatment, 8 cases returned to light perception and only one patient was permanent blindness by following up.·CONCLUSION: For patients with optic neuropathy to undergo vitrectomy surgery,using retrobulbar anesthesia have a high probability of amaurosis,peribulbar anes-thesia is safer than retrobulbar anesthesia.