AIM:To investigate the influences of correction with spectacles in middle-aged and aged patient with ametropic asthenopia on xerophthalmia. METHODS: Eighty-six xerophthalmia patients combined with ametropic asthenopia aged 40-58 years old were randomly divided into drug treated group and drug-spectacles treated group, clinical symptoms and physical signs before and after treatment were observed. RESULTS: Clinical symptoms and physical signs were improved after treatment in both groups, there were statistical differences between the two groups(P<0.05), and the curative effect in drug-spectacles group was better than that in drug treated group. CONCLUSION: Drug-spectacles treatment has better effect on improving symptoms and physical signs.