AIM:To observe the effects of method of activating blood and diuresis on central serous chorioretiopathy.METHODS:One hundred and twenty-nine eyes in 108 cases with CSC were treated in the method of activating blood and diuresis on the basis of treatment with syndrome differentiation.Deficiency of kidney was treated in the method of tonifying liver and kidney,activating blood and diuresis and modification of Wolfberry,Chrysanthemum and Rehmania Decoction;Spleen dysfunction due to dampness was treated in the method of tonifying spleen and activating blood and diuresis and modification of Ginseng,Poria and Bighead Atractylodes Powder;Liver dysfunction due to heat was treated in the method of clearing heat,activating blood and diuresis,modified Merry Life Powder.These eyes were compared with 124 eyes in 105 cases treated in common treatment with syndrome differentiation.RESULTS:After one treatment period therapy group had cure effect in 39 eyes,markedly improvement in 47 eyes,improvement in 40 eyes,failure in 3 eyes,effective rate 97.7%;control group had cure effect in 28 eyes,markedy improvement in 39 eyes,improvement in 50 eyes,failure in 7 eyes,effective rate 94.4%.Compared with twe groups,there was siganicant difference(P<0.01).After two groups were treated their vision were improved.Compared before and after treatment of each group there was siganicant difference(P<0.01);after treatment compared therapy group with control group difference was statistically significant(P<0.05).CONCLUSION:The method can improve clinical effect and patients’ vision on CSC on the basis of treatment with syndrome differentiation.