AIM:To investigate the effect of celecoxib on the inhibitor of apoptosis protein Bcl-2 in retinas of early diabetic rats. ·METHODS:Forty Wistar rats were used to establish diabetic models by intraperitoneal injecting with streptozotocin,and divided into diabetes mellitus group (n=20) and celecoxib group (n=20),ten else rats were in normal control group. All of the rats were executed 3 months later. Immunohistochemistry and computer-picture analytic system were used to observe the expression of Bcl-2 protein in retinas of rats. ·RESULTS:The expression of Bcl-2 in normal group was higher than that of celecoxib group and lower than that of diabetes mellitus group(all P<0.01). ·CONCLUSION:Celecoxib can inhibit the expression of Bcl-2 in retina of diabetes mellitus.