AIM:To observe the effects of domestic mydriatic before and during phacoemulsification. ·METHODS:The selected 200 patients were divided equally into the experiment group (zhoubian group) and the control group(Mydrin-P groups) randomly. The pupil diameter 15,20,25 minutes after three times dropping mydriatics was recorded respectively and the time of pupil started to recession one day before operation. After dropping mydriatic one hour before operation,the pupil diameter was recorded before operation,after sodium hyaluronate injected and at the end of operation. The entire operation time and the effective phaco-time was recorded. Then the data obtained from 2 groups were compared. ·RESULTS:The max-diameter of pupils in the experiment group and the control group were (7.45±0.72) mm and (7.22±0.97) mm respectively 20 minutes after dropping the mydriatic,there was no difference between the 2 groups.But the recession time in the experiment group and the control group were (2.85±0.74) hours and (2.49±0.75) hours,the difference between two groups was significant.The maintenance effect of mydriasis during phacoemulsification also has no difference between two groups regarding to the same lens nucleus hardness. ·CONCLUSION:The domestic mydriatic zhuobian has the same effect of mydriasis preoperation and during operation,but in zhoubian group the recession time was shorter than Mydrin-P group,and the difference was significant.