Corneal collagen cross-linking( CCL) is the latest corneal shape technology in clinical application in 21 century. Riboflavin,a photosensitizer,can be applied to local irradiation of the cornea by 370nm ultraviolet and it can stimulate collagen cross-linking,and increase corneal rigidity. The technology is expected to become more familiar with the corneal molding techniques such as conductive keratoplasty and corneal ring implantation for secondary treatment in clinic. These corneal molding surgeries are expected to open up a new field,and treated with new corneal disease. Ophthalmologists can reshape the corneal structure without penetrating keratoplasty or lamellar keratoplasty and other invasive techniques by CCL. Instead of corneal ring implantation,it can improve significantly treatment effect of keratoconus. Technical methods with CCL has been improved,and the treatment range has also increased. Besides progressive kera-toconus,the refractory corneal ulcer,corneal degenera-tion,corneal expansion diseases were all applied.