Proliferative retinopathies such as proliferative diabetic retinopathy(PDR) and retinopathy of prematurity(ROP), are the leading causes of blindness.These pathologies are characterized by excessive pre-retinal blood vessel growth that can ultimately lead to a fibrous scar formation and culminate in retinal detachment.This abnormal and disproportionate hyper-vascularization is a compensatory mechanism to overcome an earlier phase of microvessel degeneration and reinstate metabolic equilibrium to the hypoxic retina.To date,the treatment modalities to counter these diseases largely rely on invasive surgical interventions.In this review,tightly around the angiogenesis, we discuss the current views on mechanisms and available treatments and present future strategies to tackle these diseases.