AIM:To determine the epidemiological features of fungal keratitis in middle and lower reaches of Yangtze river. METHODS:Two hundred and twelve fungal keratitis cases were evaluated and demographic data were recorded,including age,gender,occupation,whether or not they have a history of trauma or contact lens use and course of treatment. RESULTS:The cases of fungal keratitis were increased year after year.159 patients were male,177(83.5%) were agriculture worker,the mean age was 44.5 years old,a history of trauma was present in 98 patients(46.2%).The interval between infection and presentation for examination was 3-160 days,with a mean time of 24.1 days.117(55.2%) cases were healed after medical treatment.59(27.8%)cases received keratoplasty,with a clear graft rate of 64.4%.The most common spectrums were Fusarium sp.(74.2%) and Aspergillus sp.(8.3%). CONCLUSION:In Hubei,the most common pathogenic spectrum of fungal keratitis is Fusarium sp.Fungal keratitis is a grave disease that causes blindness.It is significantly important to improve the diagnosis level and give perfect treatment.