AIM:To investigate the result of the local retinal photocoagulation in combination with phamacological treatment for patients with non-proliferative diabetic retinopathy(NPDR). METHODS:Partial photocoagulation with 532 semiconductor green laser has been used on patients with stageⅢdiabetic retinopathy(DR),combined with the administation of drugs to control blood glucose,blood pressure,blood lipid and hemorheology. RESULTS:Among 185 treated eyes,visual acuity of 168 eyes(90.8%) was improved and stabilized after treatment, decreased visual acuity and complications happened in 17 eyes(9.2%),there was significant difference between the pre-treatment and post treatment. CONCLUSION:Local retinal photocoagulation combined with drug treatment for patients with NPDR are safe and effective.