·AIM:To investigate the etiology,classification and management of post-penetrating keratoplasty glaucoma(PPKG).·METHODS:Totally 52 cases 52 eyes with secondary glaucoma after penetrating keratoplasty(PK)(197 cases,206 eyes)were retrospectively analyzed of etiology,correlated factors and treatment methods.·RESULTS:The intraocular pressure(IOP)of 34 cases became normal after drug treatment.18 cases received operation or laser therapy,in which all cases had normal IOP.·CONCLUSION:Accurate perioperative management can decrease the incidence of PPKG.The majority of secondary glaucoma can be controlled by different therapies according to different causes.·