AIM:To observe the expression of pigment epithelium-derived factor (PEDF) in human cataract lens epithelial cells,and to explore its role in the pathogenesis of cataract.·METHODS:During the cataract circular capsulorhexis of phacoemulsification surgery,the anterior lens capsule and lens epithelial cells were obtained and fixed. Immunohistochemical method was used to determine the expression of of PEDF and VEGF in lens epithelial cells.·RESULTS:There were expression of PEDF and VEGF in senile cataract crystal epithelial cells,while the high expression of PEDF was weaker than that in the VEGF.·CONCLUSION:PEDF and VEGF are expressed in senile cataract lens epithelial cells and both exist certain interactions. It may plays an important role for the pathogenesis of senile cataract.