AIM:To investigate the expression pattern and correlation of hypoxia-inducible factor-1α(HIF-1α) and stromal cell-derived factor-1(SDF-1) in the ischemic retinopathy and retinal ischemia-reperfusion.·METHODS:In order to analyze the correlation and expression between HIF-1α and SDF-1 in retinal ischemia-reperfusion model,immunohistochemical method was used.·RESULTS:In the control group,HIF-1α and SDF-1 were not expressed or slightly expressed,while that in retinal ischemia-reperfusion group began to express immediately after carotid artery ligation,ascended at 6 hour,reached peak at 12 hour,and decreased gradually after 24 hours.·CONCLUSION:HIF-1α and SDF-1 expression are closely relate to retinal ischemia-reperfusion injury,and have a collaborative relationship.