AIM:To investigate the therapeutic effect of compound anisodine in rats with retinal ischemia-reperfusion injury.·METHODS:Totally 30 adult female rats were divided into three groups at random. Group 1(n=10):normal control;group 2(n=10):high intraocular pressure (IOP)induced ocular ischemia model; group 3(n=10):compound anisodine treatment. At the 1 day,3,7 days the recovery condition of a-wave and b-wave by electroretinogram were observed in each group respectively. The morphology of retinal were observed by light microscope(n=2) in each group randomly. Retinal morphology and ganglion cells mitochondrion were evaluated by electron microscope.·RESULTS:In our research,the recovery of b-wave in group 3 were better than that in group 1 and 2,and showed significant difference(P<0.01).In addition,group 3 ganglion cells mitochondrion swelling were lighter than that in group 2.·CONCLUSION:Compound anisodine can ameliorate the retinal ischemia-reperfusion injury in rats.