AIM:To determine the prognostic factor of laser treatment for diabetic macular edema(DME).·METHODS:Totally 80 patients 80 eyes with type 2 diabetes were enrolled in the retrospective study. All the subjects underwent local/grid laser coagulation treatment for DME. The clinical data were collected and analyzed. ·RESULTS:HbA1c,hyperlipemia and the type of DME were indicated as prognostic factors of laser treatment for DME by Logistic regression analysis and showed significant difference(P<0.05). ·CONCLUSION:Prognosis of laser treatment for DME is related with HbA1c,hyperlipemia and the type of DME.