AIM:To observe the therapeutic effect of compound anisodine combined with triamcinolone acetonide(TA) for anterior ischemic optic neuropathy(AION). ·METHODS:Totally 58 patients 60 eyes diagnosed with AION were randomly divided into two groups:29 patients 30 eyes underwent superficial temporal artery injection with compound anisodine combined with triamcinolone acetonide(TA)(20mg) posterior Tenon’s capsule injection (treatment group),and the other 29 patients 30 eyes underwent superficial temporal artery injection with compound anisodine (2mL/d)(control group) with the period of treatment of 15 days. The changes of visual acuity and optic papilla swelling were recorded after treatment. The visual field was counterchecked in the patients who had underwent the examination before the treatment.·RESULTS:The visual acuity was improved in treatment group more than that in control group and there was statistical difference(χ2=17.8,P<0.01). In treatment group 14 eyes underwent the examination of vision field and improved in 12 (86%) and remainded unchanged in 2(14%). In control group 13 eyes underwent the examination of vision field and improved in 4(31%) and remainded unchanged in 9(69%). The change of vision field between two groups was statistical different (χ2=8.68,P<0.05). ·CONCLUSION:Compound anisodine combined with TA is more effective than compound anisodine separately on AION.