AIM:To analyze the clinical epidemiology of diabetic retinopathy and its early intervention in economic and technological development zone of Qingdao.·METHODS:Totally 600 patients with diabetes underwent free screening and the examination of ophthalmic fundus in community. The early intervention and treatment were performed for diagnosed diabetic retinopathy patients.·RESULTS:Totally 600 patients with diabetes underwent eye examinations,and the detection rate of diabetic retinopathy was in 17.8%(107 cases);And diagnosed 107 patients were performed the fundus fluorescein angiography,including 79 patients with non-proliferative lesions(73.8%) and 28 patients with proliferative lesions,(26.2%).The duration time,glycemic control,blood pressure,blood lipids,diabetes,kidney disease related factors were analyzed. Diabetic retinopathy patients,duration time below 10 years were in 12 cases,accounting for 11.2% and above 10 years in 95 cases,accounting for 88.8%; with hypertension were in 75 cases,accounting for 70.1%; combined hyperlipidemia in 66 cases,accounting for 61.7%; diabetic nephropathy in 37 cases,accounting for 34.5%.·CONCLUSION:The long duration time,fasting hyperglycemia,hypertension,hyperlipidemia,diabetes mellitus and diabetic nephropathy are main high-risk factors of retinopathy,and close monitor and regular fundus examination are key factors for prevention and treatment of diabetic retinopathy.