AIM:To observe therapeutic effects of excision of pterygium with the amniotic membrane transplantation and the auto-corneal limbus stem cell transplantation.·METHODS:A total of 82 patients 85 eyes which underwent excision of pterygium were randomly divided into 2 groups:Group A (40 eyes),amniotic membrane transplantation group; Group B (45 eyes),auto-corneal limbus stem cell transplantation group.·RESULTS:Followed up for 9 to 32 months after operation,2 cases recurred in group A and the recurrence rate was 5%,while the cure rate was 100% in group B. recurrence rate was not statistically different between the two groups.·CONCLUSION:Both methods have achieved good effect for pterygium,and pterygium excision with auto-corneal limbal stem cell transplantation has a better effect.